The whole of the genome sequence will change pregnancy
The world It predicts the light of light, the pregnancy changes substantially. “I think people’s default method is to choose children through IVF and fetal screening,” she said. “There is only one broad risk that you can be separated from the table.”
Siddiqui is the founder and CEO of Orchid, a biotechnology company that offers a complete fetal screening for IVF. Orchid says that by analyzing the DNA of different embryos before selecting which planting, parents can affect the risk of their children’s growth due to genetic base conditions. Siddiqui spoke to George’s Church of Genomic and Professor of Genetics at Harvard Medical School-at the Boston Summit, discovering the promise and potential of the whole genome sequence.
It is estimated that 4 % of people around the world have a disease due to a single genetic mutation. “With fetal screening,” these uniform diseases can be completely avoided, “Siddiqui said. More importantly, almost half of the world’s population suffer from a chronic disease with at least some genetic basis. Siddiqui said, analyze the five embryos before planting, and “now you can reduce the genetic component of this risk with these two -digit numbers. You are at the worst of 30 % and at best up to 80 %.” (You can watch the session in the film below; at first there is a problem with the Siddiqui Noor microphone, which is about 6 minutes.)
The Orchid website, which can be noted the statistical analysis of risk reduction through fetal screening, explains that the precise reduction in relative risk depends on various factors. These cases, including the other, are prevalent, the number of fetuses being analyzed and the amount of influence on genetic types that affect the possibility of the disease.
The church is an orchid investor and believes that the type of fetal screening it offers is one of the most affordable medical technologies ever created. The human genome project costs $ 3 billion to draw all human genes, but since then, the sequence of a genome has declined dramatically. The Orchid genome sequence costs several thousand dollars in each fetus. The church believes that “perhaps the 10 -fold investment return.” “A large part of our health care costs, psychological problems and family problems can be solved in this way.”
Siddiqui has used this technology to display its embryos. She shared the story of her mother, who experienced adult blindness because of the genetic change in her genome. “Fortunately, all embryos are negative for it,” he said. “But another thing that is very common in most South Asian families is a great risk for heart disease and diabetes. So this is really something we prioritize.”
The blind that Siddiqui described is uniform, meaning that it was created with only a single genetic change. Siddiqui said: “Among the known single -gene diseases,” 95 % have no cure, they are much less than treatment. ” But many other conditions – such as schizophrenia, or bipolar disorder or cardiac disease – are polygenic caused by the cumulative effect of many genetic types. For these, genetic risk scores can potentially determine the risk of a disease and can be calculated for both adults and fetuses. Orchid fetus tests are looking for both types of disease.
