Scientists made human eggs from skin cells and used them to form a fetus
Mitinori Saitou first recorded in 2018 at the University of Kyoto how his team turned human blood cells into stem cells, which made them human eggs, but they were very immature to fertilize the fetus.
Us Startup Concept Bioscout Science, IVY NATAL, GAMTO and OVELLE BIO are all building eggs or sperm in the laboratory.
But the outlook creates significant ethical questions about how to use this technology. In a 2017 editorial, biologists warned that IVG “may increase the” fetal agriculture “spell on a currently unimaginable scale.” It seems that this can allow anyone of any age to have a child. And with progress in fetal screening, future fertility clinics can use IVG to create massive number of fetuses and then select things with the most desirable properties. Gene editing can also be used with IVG to eliminate DNA causing disease or create new traits.
Amato says it will probably take another decade of research before the IVG can be safe or effective to be tested in people. Even then, it is unclear whether this technique will be permitted in the United States, as a congress ride will prohibit the Food and Drug Administration from considering clinical tests that include genetic manipulation of the fetus to intend to create a child.
“Their approach is very advanced and organized,” says Hayesa, now a professor at the University of Osaka. However, due to the high levels of chromosomal errors, “it is very ineffective and risky to apply immediately to clinical applications.”
Also, since their process requires donor eggs, it can limit its use as a treatment for infertility. With the greater popularity of IVF, demand for donor eggs is increasing and their use can include waiting time.
Amandar Clark, a reproductive scientist and stem cell biologist in UCLA who was not involved, agrees that in his current form, Mitomiosis is not ready to use fertility. But in the meantime, this research has other applications.
“Mitomiosis technology is an important technical innovation and can be very valuable to our understanding of meiosis’s biology in human eggs. Miouz errors increase with age, so understanding the causes of meiosis is an important research area,” Clark says.
